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Metabolic perturbation of an essential pathway: evaluation of a glycine precursor of Coenzyme A

Pantetheine, and its corresponding disulfide pantethine, play a key role in metabolism as a building block of coenzyme A (CoA), an essential cofactor utilized in ~4% of primary metabolism and central to fatty acid, polyketide, and non-ribosomal peptide synthases. Using a combination of recombinant e...

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Bibliografske podrobnosti
Main Authors: Rothmann, Michael, Kang, MinJin, Villa, Reymundo, Ntai, Ioanna, La Clair, James J., Kelleher, Neil L., Chapman, Eli, Burkart, Michael D.
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3657554/
https://ncbi.nlm.nih.gov/pubmed/23550886
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja400795m
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