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Chemical perturbation of Mcl-1 pre-mRNA splicing to induce apoptosis in cancer cells
The myeloid cell leukemia-1 (MCL1) gene encodes antiapoptotic Mcl-1(L) and proapoptotic Mcl-1(S) proteins. In cancer, the Mcl-1(L)/Mcl-1(S) ratio is very high, accounting for the antiapoptotic nature of cancer cells. As such, reducing this ratio can render the cancer cells prone to apoptosis. The Mc...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3657302/ https://ncbi.nlm.nih.gov/pubmed/23485022 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cb300602j |
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