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Solvation in protein folding analysis: Combination of theoretical and experimental approaches

An effort to combine theoretical analyses and protein engineering methods has been made to probe the folding mechanism of SH3 by using Energy Landscape Theory and a φ-value analysis. Particular emphasis was given to core residues and the effect of desolvation during the folding event by replacing th...

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Detalles Bibliográficos
Main Authors: Fernández-Escamilla, A. M., Cheung, M. S., Vega, M. C., Wilmanns, M., Onuchic, J. N., Serrano, L.
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2004
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC365706/
https://ncbi.nlm.nih.gov/pubmed/14978284
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0304180101
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