Src-Mediated Phosphorylation of the Tyrosine Phosphatase PRL-3 Is Required for PRL-3 Promotion of Rho Activation, Motility and Invasion

The metastasis-associated tyrosine phosphatase PRL-3/PTP4A is upregulated in numerous cancers, but the mechanisms modulating PRL-3 activity other than its expression levels have not been investigated. Here we report evidence for both Src-dependent tyrosine phosphorylation of PRL-3 and Src-mediated r...

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Библиографические подробности
Главные авторы: Fiordalisi, James J., Dewar, Brian J., Graves, Lee M., Madigan, James P., Cox, Adrienne D.
Формат: Artigo
Язык:Inglês
Опубликовано: Public Library of Science 2013
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Research Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3656837/
https://ncbi.nlm.nih.gov/pubmed/23691193
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0064309
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