Interaction of a hepatoma-specific nuclear factor with transcription-regulatory sequences of the human alpha-fetoprotein and albumin genes.

DNase I footprinting and gel mobility shift analysis showed that an HuH-7 hepatoma nuclear protein, termed AFP1, binds specifically to an AT-rich sequence, TGATTAATAATTACA, in domain B of the human alpha-fetoprotein enhancer. No such binding activity was found in HeLa cell nuclei. Transient transfec...

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Bibliographic Details
Published in:Mol Cell Biol
Main Authors: Sawadaishi, K, Morinaga, T, Tamaoki, T
Format: Artigo
Language:Inglês
Published: Taylor & Francis 1988
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC365620/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2468995/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.8.12.5179
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