Structural Basis of HCV Neutralization by Human Monoclonal Antibodies Resistant to Viral Neutralization Escape

The high mutation rate of hepatitis C virus allows it to rapidly evade the humoral immune response. However, certain epitopes in the envelope glycoproteins cannot vary without compromising virus viability. Antibodies targeting these epitopes are resistant to viral escape from neutralization and unde...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Krey, Thomas, Meola, Annalisa, Keck, Zhen-yong, Damier-Piolle, Laurence, Foung, Steven K. H., Rey, Felix A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2013
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3656090/
https://ncbi.nlm.nih.gov/pubmed/23696737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003364
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