Hepatic Stellate Cell–Targeted Delivery of Hepatocyte Growth Factor Transgene via Bile Duct Infusion Enhances Its Expression at Fibrotic Foci to Regress Dimethylnitrosamine-Induced Liver Fibrosis

Liver fibrosis generates fibrotic foci with abundant activated hepatic stellate cells and excessive collagen deposition juxtaposed with healthy regions. Targeted delivery of antifibrotic therapeutics to hepatic stellate cells (HSCs) might improve treatment outcomes and reduce adverse effects on heal...

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Autores principales: Narmada, Balakrishnan Chakrapani, Kang, Yuzhan, Venkatraman, Lakshmi, Peng, Qiwen, Sakban, Rashidah Binte, Nugraha, Bramasta, Jiang, Xuan, Bunte, Ralph M., So, Peter T.C., Tucker-Kellogg, Lisa, Mao, Hai-Quan, Yu, Hanry
Formato: Artigo
Lenguaje:Inglês
Publicado: Mary Ann Liebert, Inc. 2013
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3655631/
https://ncbi.nlm.nih.gov/pubmed/23527815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2012.158
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