Hepatic Stellate Cell–Targeted Delivery of Hepatocyte Growth Factor Transgene via Bile Duct Infusion Enhances Its Expression at Fibrotic Foci to Regress Dimethylnitrosamine-Induced Liver Fibrosis

Liver fibrosis generates fibrotic foci with abundant activated hepatic stellate cells and excessive collagen deposition juxtaposed with healthy regions. Targeted delivery of antifibrotic therapeutics to hepatic stellate cells (HSCs) might improve treatment outcomes and reduce adverse effects on heal...

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Detalhes bibliográficos
Main Authors: Narmada, Balakrishnan Chakrapani, Kang, Yuzhan, Venkatraman, Lakshmi, Peng, Qiwen, Sakban, Rashidah Binte, Nugraha, Bramasta, Jiang, Xuan, Bunte, Ralph M., So, Peter T.C., Tucker-Kellogg, Lisa, Mao, Hai-Quan, Yu, Hanry
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2013
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3655631/
https://ncbi.nlm.nih.gov/pubmed/23527815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2012.158
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