Mammalian DNA2 helicase/nuclease cleaves G-quadruplex DNA and is required for telomere integrity

Efficient and faithful replication of telomeric DNA is critical for maintaining genome integrity. The G-quadruplex (G4) structure arising in the repetitive TTAGGG sequence is thought to stall replication forks, impairing efficient telomere replication and leading to telomere instabilities. However,...

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Detalhes bibliográficos
Main Authors: Lin, Weiqiang, Sampathi, Shilpa, Dai, Huifang, Liu, Changwei, Zhou, Mian, Hu, Jenny, Huang, Qin, Campbell, Judith, Shin-Ya, Kazuo, Zheng, Li, Chai, Weihang, Shen, Binghui
Formato: Artigo
Idioma:Inglês
Publicado em: European Molecular Biology Organization 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3655473/
https://ncbi.nlm.nih.gov/pubmed/23604072
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2013.88
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