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DERIVED SNP ALLELES ARE USED MORE FREQUENTLY THAN ANCESTRAL ALLELES AS RISK-ASSOCIATED VARIANTS IN COMMON HUMAN DISEASES
Evolutionary aspects of the genetic architecture of common human diseases remain enigmatic. The results of more than 200 genome-wide association studies published to date were compiled in a catalog (http://www.genome.gov/26525384/). We used cataloged data to determine whether derived (mutant) allele...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2012
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3655427/ https://ncbi.nlm.nih.gov/pubmed/22809343 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1142/S0219720012410089 |
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