Phosphodiesterase Inhibition Rescues Chronic Cognitive Deficits Induced by Traumatic Brain Injury

Traumatic brain injury (TBI) modulates several cell signaling pathways in the hippocampus critical for memory formation. Previous studies have found that the cAMP-protein kinase A signaling pathway is downregulated after TBI and that treatment with a phosphodiesterase (PDE) 4 inhibitor rolipram resc...

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Main Authors: Titus, David J., Sakurai, Atsushi, Kang, Yuan, Furones, Concepcion, Jergova, Stanislava, Santos, Rosmery, Sick, Thomas J., Atkins, Coleen M.
Format: Artigo
Jezik:Inglês
Izdano: Society for Neuroscience 2013
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3655415/
https://ncbi.nlm.nih.gov/pubmed/23516287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5133-12.2013
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