Genetic and epigenetic mutations affect the DNA binding capability of human ZFP57 in transient neonatal diabetes type 1

In the mouse, ZFP57 contains three classical Cys(2)His(2) zinc finger domains (ZF) and recognizes the methylated TGC(met)CGC target sequence using the first and the second ZFs. In this study, we demonstrate that the human ZFP57 (hZFP57) containing six Cys(2)His(2) ZFs, binds the same methylated sequ...

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Autors principals: Baglivo, Ilaria, Esposito, Sabrina, De Cesare, Lucia, Sparago, Angela, Anvar, Zahra, Riso, Vincenzo, Cammisa, Marco, Fattorusso, Roberto, Grimaldi, Giovanna, Riccio, Andrea, Pedone, Paolo V.
Format: Artigo
Idioma:Inglês
Publicat: Elsevier Science B.V 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3655262/
https://ncbi.nlm.nih.gov/pubmed/23499433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2013.02.045
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