ApoE and TDP-43 neuropathology in two siblings with familial FTLD-motor neuron disease

Frontotemporal lobar degeneration with motor neuron disease (FTLD-MND) is characterized by neuronal cytoplasmic inclusions containing TDP-43. Apolipoprotein E4 (apoE4), derived from the apoE ε4 allele, enhances brain atrophy in FTLD through unknown mechanisms. Here, we studied two siblings with C9OR...

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Detalhes bibliográficos
Main Authors: Vossel, Keith A., Bien-Ly, Nga, Bernardo, Aubrey, Rascovsky, Katya, Karydas, Anna, Rabinovici, Gil D., Sidhu, Manu, Huang, Eric J., Miller, Bruce L., Huang, Yadong, Seeley, William W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3655113/
https://ncbi.nlm.nih.gov/pubmed/22512241
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/13554794.2012.667124
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