Imatinib mesylate inhibits cell growth of malignant peripheral nerve sheath tumors in vitro and in vivo through suppression of PDGFR-β

BACKGROUND: Malignant peripheral nerve sheath tumors (MPNSTs) are highly aggressive and associated with poor prognosis. Basic research to develop new treatment regimens is critically needed. METHODS: The effects of imatinib mesylate on MPNSTs were examined in six human MPNST cell lines and in a xeno...

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Detalhes bibliográficos
Main Authors: Ohishi, Jun, Aoki, Mikiko, Nabeshima, Kazuki, Suzumiya, Junji, Takeuchi, Tamotsu, Ogose, Akira, Hakozaki, Michiyuki, Yamashita, Yuichi, Iwasaki, Hiroshi
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3654969/
https://ncbi.nlm.nih.gov/pubmed/23642185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-13-224
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