Imatinib mesylate (Gleevec®) in advanced breast cancer-expressing C-Kit or PDGFR-β: clinical activity and biological correlations

Background: Novel molecular therapies for metastatic breast cancer (MBC) are necessary to improve the dismal prognosis of this condition. Imatinib mesylate (Gleevec®) inhibits several protein tyrosine kinases, including platelet-derived growth factor receptor (PDGFR) and c-kit, which are preferentia...

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Detalhes bibliográficos
Main Authors: Cristofanilli, M., Morandi, P., Krishnamurthy, S., Reuben, J. M., Lee, B.-N., Francis, D., Booser, D. J., Green, M. C., Arun, B. K., Pusztai, L., Lopez, A., Islam, R., Valero, V., Hortobagyi, G. N.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2008
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735063/
https://ncbi.nlm.nih.gov/pubmed/18515258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/annonc/mdn352
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