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The role of c-kit and imatinib mesylate in uveal melanoma

BACKGROUND: Uveal melanoma (UM) is the most common primary intraocular tumor in adults, leading to metastasis in 40% of the cases and ultimately to death in 10 years, despite local and/or systemic treatment. The c-kit protein (CD117) is a membrane-bound tyrosine kinase receptor and its overexpressio...

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Detalhes bibliográficos
Main Authors: Pereira, Patricia Rusa, Odashiro, Alexandre Nakao, Marshall, Jean Claude, Correa, Zelia Maria, Belfort, Rubens, Burnier, Miguel N
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2005
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1282581/
https://ncbi.nlm.nih.gov/pubmed/16236162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1477-3163-4-19
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