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Reducing MCM levels in human primary T cells during the G(0)→G(1) transition causes genomic instability during the first cell cycle

DNA replication is tightly regulated, but paradoxically there is reported to be an excess of MCM DNA replication proteins over the number of replication origins. Here, we show that MCM levels in primary human T cells are induced during the G(0)→G(1) transition and are not in excess in proliferating...

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מידע ביבליוגרפי
Main Authors: Orr, SJ, Gaymes, T, Ladon, D, Chronis, C, Czepulkowski, B, Wang, R, Mufti, GJ, Marcotte, EM, Thomas, NSB
פורמט: Artigo
שפה:Inglês
יצא לאור: 2010
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC3654664/
https://ncbi.nlm.nih.gov/pubmed/20440261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.138
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