Reducing MCM levels in human primary T cells during the G(0)→G(1) transition causes genomic instability during the first cell cycle

DNA replication is tightly regulated, but paradoxically there is reported to be an excess of MCM DNA replication proteins over the number of replication origins. Here, we show that MCM levels in primary human T cells are induced during the G(0)→G(1) transition and are not in excess in proliferating...

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Detalhes bibliográficos
Main Authors: Orr, SJ, Gaymes, T, Ladon, D, Chronis, C, Czepulkowski, B, Wang, R, Mufti, GJ, Marcotte, EM, Thomas, NSB
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3654664/
https://ncbi.nlm.nih.gov/pubmed/20440261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2010.138
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