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Dacarbazine mediates antimelanoma effects via NK cells
Melanoma is a highly chemoresistant and metastatic tumor that, in the absence of BRAF mutations, is generally treated with the alkylating agent dacarbazine (DTIC). We discovered that DTIC upregulates the expression of NKG2D ligands on tumor cells, leading to the activation of natural killer (NK) and...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Landes Bioscience
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3654594/ https://ncbi.nlm.nih.gov/pubmed/23734324 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.23714 |
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