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Mimotope vaccine efficacy gets a "boost" from native tumor antigens

Tumor-associated antigen (TAA)-targeting mimotope peptides exert more prominent immunostimulatory functions than unmodified TAAs, with the caveat that some T-cell clones exhibit a relatively low affinity for TAAs. Combining mimotope-based vaccines with native TAAs in a prime-boost setting significan...

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Detalles Bibliográficos
Main Authors: Buhrman, Jonathan D., Slansky, Jill E.
Formato: Artigo
Idioma:Inglês
Publicado: Landes Bioscience 2013
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3654579/
https://ncbi.nlm.nih.gov/pubmed/23734309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/onci.23492
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