Biophysical Fragment Screening of the β(1)-Adrenergic Receptor: Identification of High Affinity Arylpiperazine Leads Using Structure-Based Drug Design

[Image: see text] Biophysical fragment screening of a thermostabilized β(1)-adrenergic receptor (β(1)AR) using surface plasmon resonance (SPR) enabled the identification of moderate affinity, high ligand efficiency (LE) arylpiperazine hits 7 and 8. Subsequent hit to lead follow-up confirmed the acti...

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Päätekijät: Christopher, John A., Brown, Jason, Doré, Andrew S., Errey, James C., Koglin, Markus, Marshall, Fiona H., Myszka, David G., Rich, Rebecca L., Tate, Christopher G., Tehan, Benjamin, Warne, Tony, Congreve, Miles
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Chemical Society 2013
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3654563/
https://ncbi.nlm.nih.gov/pubmed/23517028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400140q
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