Biophysical Fragment Screening of the β(1)-Adrenergic Receptor: Identification of High Affinity Arylpiperazine Leads Using Structure-Based Drug Design

[Image: see text] Biophysical fragment screening of a thermostabilized β(1)-adrenergic receptor (β(1)AR) using surface plasmon resonance (SPR) enabled the identification of moderate affinity, high ligand efficiency (LE) arylpiperazine hits 7 and 8. Subsequent hit to lead follow-up confirmed the acti...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Christopher, John A., Brown, Jason, Doré, Andrew S., Errey, James C., Koglin, Markus, Marshall, Fiona H., Myszka, David G., Rich, Rebecca L., Tate, Christopher G., Tehan, Benjamin, Warne, Tony, Congreve, Miles
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2013
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3654563/
https://ncbi.nlm.nih.gov/pubmed/23517028
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm400140q
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados