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Inter-channel scaffolding of presynaptic CaV2.2 via the C terminal PDZ ligand domain

Calcium entry through CaV2.2 calcium channels clustered at the active zone (AZ) of the presynaptic nerve terminal gates synaptic vesicle (SV) fusion and the discharge of neurotransmitters, but the mechanism of channel scaffolding remains poorly understood. Recent studies have implicated the binding...

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Autors principals: Gardezi, Sabiha R., Li, Qi, Stanley, Elise F.
Format: Artigo
Idioma:Inglês
Publicat: The Company of Biologists 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3654268/
https://ncbi.nlm.nih.gov/pubmed/23789098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.20134267
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