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Direct evidence for the adaptive role of copy number variation on antifolate susceptibility in Plasmodium falciparum
Resistance to antimalarials targeting the folate pathway is widespread. GTP-cyclohydrolase (gch1), the first enzyme in this pathway, exhibits extensive copy number variation (CNV) in parasite isolates from areas with a history of longstanding antifolate use. Increased CN of gch1 is associated with a...
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| 主要な著者: | , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3654098/ https://ncbi.nlm.nih.gov/pubmed/23347134 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.12162 |
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