Direct evidence for the adaptive role of copy number variation on antifolate susceptibility in Plasmodium falciparum

Resistance to antimalarials targeting the folate pathway is widespread. GTP-cyclohydrolase (gch1), the first enzyme in this pathway, exhibits extensive copy number variation (CNV) in parasite isolates from areas with a history of longstanding antifolate use. Increased CN of gch1 is associated with a...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Heinberg, Adina, Siu, Edwin, Stern, Chaya, Lawrence, Elizabeth A, Ferdig, Michael T, Deitsch, Kirk W, Kirkman, Laura A
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2013
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3654098/
https://ncbi.nlm.nih.gov/pubmed/23347134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/mmi.12162
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