Copper Chelator ATN-224 Induces Peroxynitrite-Dependent Cell Death in Hematological Malignancies

Chemoresistance, due to oxidative stress resistance or upregulation of Bcl-2, contributes to poor outcome in the treatment of hematological malignancies. In this study, we utilize the copper chelator drug, ATN-224 (choline tetrathiomolybdate), to induce cell death in oxidative stress resistant cells...

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Main Authors: Lee, Kristy, Briehl, Margaret M., Mazar, Andrew P., Batinic-Haberle, Ines, Reboucas, Julio S., Glinsmann-Gibson, Betty, Rimsza, Lisa M., Tome, Margaret E.
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3654089/
https://ncbi.nlm.nih.gov/pubmed/23416365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2013.02.003
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