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A Synthetic Biology Framework for Programming Eukaryotic Transcription Functions

Eukaryotic transcription factors (TFs) perform complex and combinatorial functions within transcriptional networks. Here, we present a synthetic framework for systematically constructing eukaryotic transcription functions using artificial zinc fingers, modular DNA-binding domains found within many e...

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Detalhes bibliográficos
Main Authors: Khalil, Ahmad S., Lu, Timothy K., Bashor, Caleb J., Ramirez, Cherie L., Pyenson, Nora C., Joung, J. Keith, Collins, James J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3653585/
https://ncbi.nlm.nih.gov/pubmed/22863014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2012.05.045
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