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GARP-TGFβ complexes negatively regulate Treg cell development and maintenance of peripheral CD4+ T cells in vivo
The role of surface bound TGFβ on regulatory T cells (Tregs) and the mechanisms mediating its functions are not well defined. We recently identified a cell surface molecule called GARP, which is expressed specifically on activated Tregs and was found to bind latent-TGFβ and mediate a portion of Treg...
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| Главные авторы: | , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3653571/ https://ncbi.nlm.nih.gov/pubmed/23576681 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1300065 |
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