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GARP-TGFβ complexes negatively regulate Treg cell development and maintenance of peripheral CD4+ T cells in vivo

The role of surface bound TGFβ on regulatory T cells (Tregs) and the mechanisms mediating its functions are not well defined. We recently identified a cell surface molecule called GARP, which is expressed specifically on activated Tregs and was found to bind latent-TGFβ and mediate a portion of Treg...

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Bibliografiske detaljer
Main Authors: Zhou, Angela X., Kozhaya, Lina, Fujii, Hodaka, Unutmaz, Derya
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3653571/
https://ncbi.nlm.nih.gov/pubmed/23576681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1300065
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