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Complement regulates conventional DC-mediated NK-cell activation by inducing TGF-β1 in Gr-1(+) myeloid cells
Complement activation modulates DC-mediated T-cell activation, but whether complement affects DC-mediated priming of NK cells is unknown. Here we demonstrate that conventional DCs (cDCs) from C3(–/–) and C5aR(–/–) mice are hyper-responsive to polyI:C, a TLR3 ligand, leading to enhanced NK-cell activ...
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| Autores principales: | , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2012
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3653187/ https://ncbi.nlm.nih.gov/pubmed/22535677 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201142290 |
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