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Activation of α6-containing GABA(A) receptors by pentobarbital occurs through a different mechanism than activation by GABA
The GABA(A) receptors are ligand-gated chloride channels which are the targets for many clinically used sedatives, including the barbiturates. The barbiturate pentobarbital acts through multiple sites on the GABA(A) receptor. At low concentrations (μM), it acts as a positive allosteric modulator whi...
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2010
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3652006/ https://ncbi.nlm.nih.gov/pubmed/20109529 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2010.01.041 |
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