BMP2 inhibits TGF-β-induced pancreatic stellate cell activation and extracellular matrix formation

Activation of pancreatic stellate cells (PSCs) by transforming growth factor (TGF)-β is the key step in the development of pancreatic fibrosis, a common pathological feature of chronic pancreatitis (CP). Bone morphogenetic proteins (BMPs), members of the TGF-β superfamily, have anti-fibrogenic funct...

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Autors principals: Gao, Xuxia, Cao, Yanna, Yang, Wenli, Duan, Chaojun, Aronson, Judith F., Rastellini, Cristiana, Chao, Celia, Hellmich, Mark R., Ko, Tien C.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2013
Matèries:
Pancreas
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3652003/
https://ncbi.nlm.nih.gov/pubmed/23429583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00306.2012
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