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Evaluation of a System to Screen for Stimulators of Nonspecific DNA Nicking by HIV-1 Integrase: Application to a Library of 50,000 Compounds
BACKGROUND: In addition to activities needed to catalyze integration, retroviral integrases exhibit nonspecific endonuclease activity that is enhanced by certain small compounds, suggesting that integrase could be stimulated to damage viral DNA before integration occurs. METHODS: A nonradioactive, p...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3651814/ https://ncbi.nlm.nih.gov/pubmed/21984686 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3851/IMP1857 |
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