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A Nonradioactive Plate-Based Assay for Stimulators of Nonspecific DNA Nicking by HIV-1 Integrase and Other Nucleases
Retroviral integrase enzymes have a nonspecific endonuclease activity that is stimulated by certain compounds, suggesting that integrase could be manipulated to damage viral DNA. To identify integrase stimulator (IS) compounds as potential antiviral agents, we have developed a nonradioactive assay t...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2787845/ https://ncbi.nlm.nih.gov/pubmed/19748478 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2009.09.012 |
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