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Controlled delivery of bioactive molecules into live cells using the bacterial mechanosensitive channel MscL

Bacterial mechanosensitive channels are some of the largest pores in nature. In particular, MscL, with a pore diameter > 25 Å, allows passage of large organic ions and small proteins. Functional MscL reconstitution into lipids has been proposed for applications in vesicular-based drug release. He...

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Detalhes bibliográficos
Main Authors: Doerner, Julia F., Febvay, Sebastien, Clapham, David E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3651673/
https://ncbi.nlm.nih.gov/pubmed/22871809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms1999
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