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IL-4 and IL-13 inhibit IL-1β and TNF-α induced kinin B(1) and B(2) receptors through a STAT6-dependent mechanism

BACKGROUND AND PURPOSE: Bone resorption induced by interleukin-1β (IL-1β) and tumour necrosis factor (TNF-α) is synergistically potentiated by kinins, partially due to enhanced kinin receptor expression. Inflammation-induced bone resorption can be impaired by IL-4 and IL-13. The aim was to investiga...

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Detalhes bibliográficos
Main Authors: Souza, PPC, Brechter, AB, Reis, RI, Costa, CAS, Lundberg, P, Lerner, UH
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3651665/
https://ncbi.nlm.nih.gov/pubmed/23351078
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12116
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