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The cardiomyocyte molecular clock, regulation of Scn5a, and arrhythmia susceptibility
The molecular clock mechanism underlies circadian rhythms and is defined by a transcription-translation feedback loop. Bmal1 encodes a core molecular clock transcription factor. Germline Bmal1 knockout mice show a loss of circadian variation in heart rate and blood pressure, and they develop dilated...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3651636/ https://ncbi.nlm.nih.gov/pubmed/23364267 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00383.2012 |
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