ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models

Alzheimer’s disease (AD) is associated with impaired clearance of β-amyloid (Aβ) from the brain, a process normally facilitated by apolipoprotein E (apoE). ApoE expression is transcriptionally induced through the action of the nuclear receptors peroxisome proliferator–activated receptor gamma and li...

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Main Authors: Cramer, Paige E., Cirrito, John R., Wesson, Daniel W., Daniel Lee, C. Y., Karlo, J. Colleen, Zinn, Adriana E., Casali, Brad T., Restivo, Jessica L., Goebel, Whitney D., James, Michael J., Brunden, Kurt R., Wilson, Donald A., Landreth, Gary E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3651582/
https://ncbi.nlm.nih.gov/pubmed/22323736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1217697
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