HPV-18 E6 mutants reveal p53 modulation of viral DNA amplification in organotypic cultures

Human papillomaviruses (HPVs) amplify in differentiated strata of a squamous epithelium. The HPV E7 protein destabilizes the p130/retinoblastoma susceptibility protein family of tumor suppressors and reactivates S-phase reentry, thereby facilitating viral DNA amplification. The high-risk HPV E6 prot...

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Main Authors: Kho, Eun-Young, Wang, Hsu-Kun, Banerjee, N. Sanjib, Broker, Thomas R., Chow, Louise T.
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2013
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3651465/
https://ncbi.nlm.nih.gov/pubmed/23572574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1304855110
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