Novel 1′,1′-Chain Substituted Hexahydrocannabinols: 9β-Hydroxy-3-(1-hexyl-cyclobut-1-yl)-hexahydrocannabinol (AM2389) a Highly Potent Cannabinoid Receptor 1 (CB1) Agonist

In pursuit of a more detailed understanding of the structural requirements for the key side chain cannabinoid pharmacophore we have extended our SAR to cover a variety of conformationally modified side chains within the 9-keto and 9-hydroxyl tricyclic structures. Of the compounds described here, tho...

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Bibliografiske detaljer
Main Authors: Nikas, Spyros P., Alapafuja, Shakiru O., Papanastasiou, Ioannis, Paronis, Carol A., Shukla, Vidyanand G., Papahatjis, Demetris P., Bowman, Anna L., Halikhedkar, Aneetha, Han, Xiuwen, Makriyannis, Alexandros
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3650853/
https://ncbi.nlm.nih.gov/pubmed/20925434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm100641g
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