Crystal Structure of Quinone Reductase 2 in Complex with Resveratrol,

Resveratrol has been shown to have chemopreventive, cardioprotective, and antiaging properties. Here, we report that resveratrol is a potent inhibitor of quinone reductase 2 (QR2) activity in vitro with a dissociation constant of 35 nM and show that it specifically binds to the deep active-site clef...

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Bibliographic Details
Main Authors: Buryanovskyy, Leonid, Fu, Yue, Boyd, Molly, Ma, Yuliang, Hsieh, Tze-chen, Wu, Joseph M., Zhang, Zhongtao
Format: Artigo
Language:Inglês
Published: 2004
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3650734/
https://ncbi.nlm.nih.gov/pubmed/15350128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi049162o
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