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SerpinB1 is critical for neutrophil survival through cell-autonomous inhibition of cathepsin G
Bone marrow (BM) holds a large reserve of polymorphonuclear neutrophils (PMNs) that are rapidly mobilized to the circulation and tissues in response to danger signals. SerpinB1 is a potent inhibitor of neutrophil serine proteases neutrophil elastase (NE) and cathepsin G (CG). SerpinB1 deficiency (sB...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society of Hematology
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3650706/ https://ncbi.nlm.nih.gov/pubmed/23532733 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-09-455022 |
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