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A Yeast Chemical Genetic Screen Identifies Inhibitors of Human Telomerase
Telomerase comprises a reverse transcriptase and an internal RNA template that maintains telomeres in many eukaryotes, and it is a well-validated cancer target. However, there is a dearth of small molecules with efficacy against human telomerase in vivo. We developed a surrogate yeast high-throughpu...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3650558/ https://ncbi.nlm.nih.gov/pubmed/23521791 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2012.12.008 |
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