Protein Phosphatase 2A and DNA-dependent Protein Kinase Are Involved in Mediating Rapamycin-induced Akt Phosphorylation

Inhibition of mammalian target of rapamycin complex 1 (mTORC1), for example with rapamycin, increases Akt phosphorylation while inhibiting mTORC1 signaling. However, the underlying mechanisms have not been fully elucidated. The current study has uncovered a previously unknown mechanism underlying ra...

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Bibliographic Details
Main Authors: Li, Yikun, Wang, Xuerong, Yue, Ping, Tao, Hui, Ramalingam, Suresh S., Owonikoko, Taofeek K., Deng, Xingming, Wang, Ya, Fu, Haian, Khuri, Fadlo R., Sun, Shi-Yong
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3650361/
https://ncbi.nlm.nih.gov/pubmed/23536185
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.463679
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