A Novel Adenoviral Hybrid-vector System Carrying a Plasmid Replicon for Safe and Efficient Cell and Gene Therapeutic Applications

In dividing cells, the two aims a gene therapeutic approach should accomplish are efficient nuclear delivery and retention of therapeutic DNA. For stable transgene expression, therapeutic DNA can either be maintained by somatic integration or episomal persistence of which the latter approach would d...

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Detalhes bibliográficos
Main Authors: Voigtlander, Richard, Haase, Rudolf, Mück-Hausl, Martin, Zhang, Wenli, Boehme, Philip, Lipps, Hans-Joachim, Schulz, Eric, Baiker, Armin, Ehrhardt, Anja
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Methods - Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3650243/
https://ncbi.nlm.nih.gov/pubmed/23549553
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mtna.2013.11
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