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LGP2 Plays a Critical Role in Sensitizing mda-5 to Activation by Double-Stranded RNA
The DExD/H box RNA helicases retinoic acid-inducible gene-I (RIG-I) and melanoma differentiation associated gene-5 (mda-5) sense viral RNA in the cytoplasm of infected cells and activate signal transduction pathways that trigger the production of type I interferons (IFNs). Laboratory of genetics and...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Public Library of Science
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3650065/ https://ncbi.nlm.nih.gov/pubmed/23671710 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0064202 |
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