Human Rotavirus VP6-Specific Antibodies Mediate Intracellular Neutralization by Binding to a Quaternary Structure in the Transcriptional Pore

Several live attenuated rotavirus (RV) vaccines have been licensed, but the mechanisms of protective immunity are still poorly understood. The most frequent human B cell response is directed to the internal protein VP6 on the surface of double-layered particles, which is normally exposed only in the...

وصف كامل

محفوظ في:
التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Aiyegbo, Mohammed S., Sapparapu, Gopal, Spiller, Benjamin W., Eli, Ilyas M., Williams, Dewight R., Kim, Robert, Lee, David E., Liu, Tong, Li, Sheng, Woods, Virgil L., Nannemann, David P., Meiler, Jens, Stewart, Phoebe L., Crowe, James E.
التنسيق: Artigo
اللغة:Inglês
منشور في: Public Library of Science 2013
الموضوعات:
Research Article
الوصول للمادة أونلاين:https://ncbi.nlm.nih.gov/pmc/articles/PMC3650007/
https://ncbi.nlm.nih.gov/pubmed/23671563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0061101
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