Human Rotavirus VP6-Specific Antibodies Mediate Intracellular Neutralization by Binding to a Quaternary Structure in the Transcriptional Pore

Several live attenuated rotavirus (RV) vaccines have been licensed, but the mechanisms of protective immunity are still poorly understood. The most frequent human B cell response is directed to the internal protein VP6 on the surface of double-layered particles, which is normally exposed only in the...

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Detalhes bibliográficos
Main Authors: Aiyegbo, Mohammed S., Sapparapu, Gopal, Spiller, Benjamin W., Eli, Ilyas M., Williams, Dewight R., Kim, Robert, Lee, David E., Liu, Tong, Li, Sheng, Woods, Virgil L., Nannemann, David P., Meiler, Jens, Stewart, Phoebe L., Crowe, James E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3650007/
https://ncbi.nlm.nih.gov/pubmed/23671563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0061101
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