Phosphatidylinositol (3,4,5)-Trisphosphate Activity Probes for the Labeling and Proteomic Characterization of Protein Binding Partners

Phosphatidylinositol polyphosphate lipids, such as phosphatidylinositol (3,4,5)-trisphosphate (PI(3,4,5)P(3)), regulate critical biological processes, many of which are aberrant in disease. These lipids often act as site-specific ligands in interactions that enforce membrane-association of protein b...

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Hauptverfasser: Rowland, Meng M., Bostic, Heidi E., Gong, Denghuang, Speers, Anna E., Lucas, Nathan, Cho, Wonhwa, Cravatt, Benjamin F., Best, Michael D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3649876/
https://ncbi.nlm.nih.gov/pubmed/22074223
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201636s
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