Immunogenicity of intrathecal plasmid gene delivery: cytokine release and effects on transgene expression

BACKGROUND: One method for the delivery of therapeutic proteins to the spinal cord is to inject nonviral gene vectors including plasmid DNA into the cerebrospinal fluid (CSF) that surrounds the spinal cord (intrathecal space). This approach has produced therapeutic benefits in animal models of disea...

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Bibliographic Details
Main Authors: Hughes, Travis S., Langer, Stephen J., Virtanen, Salla I., Chavez, Raymond A., Watkins, Linda R., Milligan, Erin D., Leinwand, Leslie A.
Format: Artigo
Language:Inglês
Published: 2009
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3649870/
https://ncbi.nlm.nih.gov/pubmed/19533588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jgm.1364
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