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Loss of the K(v)1.1 potassium channel promotes pathologic sharp waves and high frequency oscillations in in vitro hippocampal slices

In human disease, channelopathies involving functional reduction of the delayed rectifier potassium channel α-subunit K(v)1.1 – either by mutation or autoimmune inhibition – result in temporal lobe epilepsy. K(v)1.1 is prominently expressed in the axons of the hippocampal tri-synaptic pathway, sugge...

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Detalhes bibliográficos
Main Authors: Simeone, Timothy A., Simeone, Kristina A., Samson, Kaeli K., Kim, Do Young, Rho, Jong M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3648846/
https://ncbi.nlm.nih.gov/pubmed/23466697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2013.02.009
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