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The benefits of selecting phenotype-specific variants for applications of mixed models in genomics

Applications of linear mixed models (LMMs) to problems in genomics include phenotype prediction, correction for confounding in genome-wide association studies, estimation of narrow sense heritability, and testing sets of variants (e.g., rare variants) for association. In each of these applications,...

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Detalhes bibliográficos
Main Authors: Lippert, Christoph, Quon, Gerald, Kang, Eun Yong, Kadie, Carl M., Listgarten, Jennifer, Heckerman, David
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3648840/
https://ncbi.nlm.nih.gov/pubmed/23657357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep01815
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