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Further Improvements to Linear Mixed Models for Genome-Wide Association Studies
We examine improvements to the linear mixed model (LMM) that better correct for population structure and family relatedness in genome-wide association studies (GWAS). LMMs rely on the estimation of a genetic similarity matrix (GSM), which encodes the pairwise similarity between every two individuals...
Shranjeno v:
| izdano v: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group
2014
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4230738/ https://ncbi.nlm.nih.gov/pubmed/25387525 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep06874 |
| Oznake: |
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