Knockdown of Regulator of Cullins-1 (ROC1) Expression Induces Bladder Cancer Cell Cycle Arrest at the G2 Phase and Senescence

Regulator of Cullins-1 (ROC1) is a key subunit in the Cullin-RING ligase (CRL) protein complex. Overexpression of ROC1 protein is associated with tumor progression and poor prognosis of non-muscle invasive bladder transitional cell carcinoma (NMIBC). This study was designed to assess the effects of...

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Detalhes bibliográficos
Main Authors: Wang, Wei, Liu, Zhihong, Qu, Ping, Zhou, Zhengdong, Zeng, Yigang, Fan, Jie, Liu, Yong, Guo, Yifeng, Qiu, Jianxin
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3648563/
https://ncbi.nlm.nih.gov/pubmed/23667514
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0062734
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