Regulator of cullins-1 expression knockdown suppresses the malignant progression of muscle-invasive transitional cell carcinoma by regulating mTOR/DEPTOR pathway

BACKGROUND: Regulator of cullins-1 (ROC1) is a key subunit in the cullin–RING ligase (CRL) protein complex. Our previous study indicated that ROC1 was essential for bladder cancer cell survival and that ROC1 knockdown inhibited CRL activity, triggering G2 phase arrest and senescence. However, the ro...

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Detaylı Bibliyografya
Yayımlandı:Br J Cancer
Asıl Yazarlar: Wang, W, Chen, H, Liu, Z, Qu, P, Lan, J, Zou, L, Qiu, J
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group 2016
Konular:
Molecular Diagnostics
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4742580/
https://ncbi.nlm.nih.gov/pubmed/26742010
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2015.444
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